Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

被引：0
作者：
de Dios Rosado, Juan [1 ]
Rodriguez-Sosa, Miriam [1 ]
机构：
[1] UNAM, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Estado De Mexic, Mexico
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2011年 / 7卷 / 09期
关键词：
Macrophage migration inhibitory factor; Protozoan infections; Inflammatory response; Control of parasite infections; innate immune response; PLASMODIUM-FALCIPARUM MALARIA; JUVENILE IDIOPATHIC ARTHRITIS; TOLL-LIKE RECEPTOR-4; FREE-LIVING AMEBAS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; RAT CRESCENTIC GLOMERULONEPHRITIS; TRYPANOSOMA-CRUZI INFECTION; LEISHMANIA-MAJOR INFECTION; INNATE IMMUNE-RESPONSES; IN-VIVO BLOCKADE;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mo), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-alpha, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.
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页码：1239 / 1256
页数：18
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