Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

被引：1
作者：
de Dios Rosado, Juan [1 ]
Rodriguez-Sosa, Miriam [1 ]
机构：
[1] UNAM, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla 54090, Estado De Mexic, Mexico
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2011年 / 7卷 / 09期
关键词：
Macrophage migration inhibitory factor; Protozoan infections; Inflammatory response; Control of parasite infections; innate immune response; PLASMODIUM-FALCIPARUM MALARIA; JUVENILE IDIOPATHIC ARTHRITIS; TOLL-LIKE RECEPTOR-4; FREE-LIVING AMEBAS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; RAT CRESCENTIC GLOMERULONEPHRITIS; TRYPANOSOMA-CRUZI INFECTION; LEISHMANIA-MAJOR INFECTION; INNATE IMMUNE-RESPONSES; IN-VIVO BLOCKADE;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mo), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-alpha, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.
引用
收藏
页码：1239 / 1256
页数：18
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