Assessment of folate receptor-β expression in human neoplastic tissues

被引：60
作者：
Shen, Jiayin [1 ]
Putt, Karson S. [2 ]
Visscher, Daniel W. [3 ]
Murphy, Linda [4 ]
Cohen, Cynthia [5 ]
Singhal, Sunil [6 ]
Sandusky, George [7 ]
Feng, Yang
Dimitrov, Dimiter S.
Low, Philip S. [1 ,2 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Purdue Univ, Ctr Drug Discovery, W Lafayette, IN 47907 USA
[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
[4] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN USA
[5] Emory Univ Hosp, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[6] Univ Penn, Sch Med, Div Thorac Surg, Dept Surg Hosp, Philadelphia, PA 19104 USA
[7] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA
来源：
ONCOTARGET | 2015年 / 6卷 / 16期
关键词：
folate receptor; folate receptor beta; activated macrophage; tumor associated macrophage; MONOCLONAL-ANTIBODY; OVARIAN-CANCER; ALPHA; MACROPHAGES; TRANSPORT; CELLS; VINTAFOLIDE; MECHANISM; MARKER; GROWTH;
D O I：
10.18632/oncotarget.3739
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over-expression of folate receptor alpha on cancer cells has been frequently exploited for delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited information exists on expression of the beta isoform of the folate receptor in human cancers (FR-beta), we have evaluated the immunohistochemical staining pattern of FR-beta in 992 tumor sections from 20 different human cancer types using a new anti-human FR-beta monoclonal antibody. FR-beta expression was shown to be more pronounced in cells within the stroma, primarily macrophages and macrophagelike cells than cancer cells in every cancer type studied. Moreover, FR-beta expression in both cancer and stromal cells was found to be statistically more prominent in females than males. A significant positive correlation was also observed between FR-beta expression on stromal cells and both the stage of the cancer and the presence of lymph node metastases. Based on these data we conclude FR-beta may constitute a good target for specific delivery of therapeutic agents to activated macrophages and that accumulation of FR-beta positive macrophages in the stroma could serve as a useful indicator of a tumor's metastatic potential.
引用
收藏
页码：14700 / 14709
页数：10
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