Assessment of folate receptor-β expression in human neoplastic tissues

被引：60
作者：
Shen, Jiayin [1 ]
Putt, Karson S. [2 ]
Visscher, Daniel W. [3 ]
Murphy, Linda [4 ]
Cohen, Cynthia [5 ]
Singhal, Sunil [6 ]
Sandusky, George [7 ]
Feng, Yang
Dimitrov, Dimiter S.
Low, Philip S. [1 ,2 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Purdue Univ, Ctr Drug Discovery, W Lafayette, IN 47907 USA
[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
[4] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN USA
[5] Emory Univ Hosp, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[6] Univ Penn, Sch Med, Div Thorac Surg, Dept Surg Hosp, Philadelphia, PA 19104 USA
[7] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA
来源：
ONCOTARGET | 2015年 / 6卷 / 16期
关键词：
folate receptor; folate receptor beta; activated macrophage; tumor associated macrophage; MONOCLONAL-ANTIBODY; OVARIAN-CANCER; ALPHA; MACROPHAGES; TRANSPORT; CELLS; VINTAFOLIDE; MECHANISM; MARKER; GROWTH;
D O I：
10.18632/oncotarget.3739
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over-expression of folate receptor alpha on cancer cells has been frequently exploited for delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited information exists on expression of the beta isoform of the folate receptor in human cancers (FR-beta), we have evaluated the immunohistochemical staining pattern of FR-beta in 992 tumor sections from 20 different human cancer types using a new anti-human FR-beta monoclonal antibody. FR-beta expression was shown to be more pronounced in cells within the stroma, primarily macrophages and macrophagelike cells than cancer cells in every cancer type studied. Moreover, FR-beta expression in both cancer and stromal cells was found to be statistically more prominent in females than males. A significant positive correlation was also observed between FR-beta expression on stromal cells and both the stage of the cancer and the presence of lymph node metastases. Based on these data we conclude FR-beta may constitute a good target for specific delivery of therapeutic agents to activated macrophages and that accumulation of FR-beta positive macrophages in the stroma could serve as a useful indicator of a tumor's metastatic potential.
引用
收藏
页码：14700 / 14709
页数：10
相关论文
共 37 条
  • [1] Folate receptors
    Antony, AC
    [J]. ANNUAL REVIEW OF NUTRITION, 1996, 16 : 501 - 521
  • [2] The folate receptor as a rational therapeutic target for personalized cancer treatment
    Assaraf, Yehuda G.
    Leamon, Christopher P.
    Reddy, Joseph A.
    [J]. DRUG RESISTANCE UPDATES, 2014, 17 (4-6) : 89 - 95
  • [3] Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy
    Elnakat, H
    Ratnam, M
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (08) : 1067 - 1084
  • [4] A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity
    Feng, Yang
    Shen, Jiayin
    Streaker, Emily D.
    Lockwood, Michael
    Zhu, Zhongyu
    Low, Philip S.
    Dimitrov, Dimiter S.
    [J]. ARTHRITIS RESEARCH & THERAPY, 2011, 13 (02)
  • [5] Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors
    Fisher, Ronald E.
    Siegel, Barry A.
    Edell, Steven L.
    Oyesiku, Nelson M.
    Morgenstern, David E.
    Messmann, Richard A.
    Amato, Robert J.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (06) : 899 - 906
  • [6] 5-METHYLTETRAHYDROFOLATE TRANSPORT IN BASOLATERAL MEMBRANE-VESICLES FROM HUMAN LIVER
    HORNE, DW
    REED, KA
    HOEFS, J
    SAID, HM
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1993, 58 (01) : 80 - 84
  • [7] Jhaveri MS, 2004, MOL CANCER THER, V3, P1505
  • [8] Kelley KMM, 2003, CANCER RES, V63, P2820
  • [9] Farletuzumab, a Humanized Monoclonal Antibody against Folate Receptor α, in Epithelial Ovarian Cancer: a Phase I Study
    Konner, Jason A.
    Bell-McGuinn, Katherine M.
    Sabbatini, Paul
    Hensley, Martee L.
    Tew, William P.
    Pandit-Taskar, Neeta
    Els, Nicholas Vander
    Phillips, Martin D.
    Schweizer, Charles
    Weil, Susan C.
    Larson, Steven M.
    Old, Lloyd J.
    [J]. CLINICAL CANCER RESEARCH, 2010, 16 (21) : 5288 - 5295
  • [10] Clinical Significance of Folate Receptor β-expressing Tumor-associated Macrophages in Pancreatic Cancer
    Kurahara, Hiroshi
    Takao, Sonshin
    Kuwahata, Taisaku
    Nagai, Taku
    Ding, Qiang
    Maeda, Koki
    Shinchi, Hiroyuki
    Mataki, Yuko
    Maemura, Kosei
    Matsuyama, Takami
    Natsugoe, Shoji
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (07) : 2264 - 2271
1234