A Repulsive Environment Induces Neurodegeneration of Midbrain Dopaminergic Neurons

被引：4
作者：
Santiago-Lopez, Angel J. [1 ,2 ]
机构：
[1] Georgia Inst Technol, Interdisciplinary Bioengn Grad Program, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
来源：
JOURNAL OF NEUROSCIENCE | 2018年 / 38卷 / 06期
基金：
美国国家科学基金会;
关键词：
PARKINSONS-DISEASE; GUIDANCE MOLECULE; AXON GUIDANCE; CELL-DEATH; DEGENERATION; MODEL; REGENERATION; ACTIVATION; SURVIVAL; SYSTEM;
D O I：
10.1523/JNEUROSCI.3070-17.2017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
[No abstract available]
引用
收藏
页码：1323 / 1325
页数：3
相关论文
共 20 条
[1]   Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and α-synuclein-deleted mice [J].
Alvarez-Fischer, Daniel ;
Henze, Carmen ;
Strenzke, Corinna ;
Westrich, Jan ;
Ferger, Boris ;
Hoeglinger, Guenter U. ;
Oertel, Wolfgang H. ;
Hartmann, Andreas .
EXPERIMENTAL NEUROLOGY, 2008, 210 (01) :182-193
[2]   Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death [J].
Bossers, Koen ;
Meerhoff, Gideon ;
Balesar, Rawien ;
van Dongen, Jeroen W. ;
Kruse, Chris G. ;
Swaab, Dick F. ;
Verhaagen, Joost .
BRAIN PATHOLOGY, 2009, 19 (01) :91-107
[3]   Clinical Progression in Parkinson Disease and the Neurobiology of Axons [J].
Cheng, Hsiao-Chun ;
Ulane, Christina M. ;
Burke, Robert E. .
ANNALS OF NEUROLOGY, 2010, 67 (06) :715-725
[4]   Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC [J].
Conrad, Sabine ;
Genth, Harald ;
Hofmann, Fred ;
Just, Ingo ;
Skutella, Thomas .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (22) :16423-16433
[5]   Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease [J].
Dijkstra, Anke A. ;
Ingrassia, Angela ;
de Menezes, Renee X. ;
van Kesteren, Ronald E. ;
Rozemuller, Annemieke J. M. ;
Heutink, Peter ;
van de Berg, Wilma D. J. .
PLOS ONE, 2015, 10 (06)
[6]   Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system [J].
Dubreuil, CI ;
Winton, MJ ;
McKerracher, L .
JOURNAL OF CELL BIOLOGY, 2003, 162 (02) :233-243
[7]   Unc5B associates with LARG to mediate the action of repulsive guidance molecule [J].
Hata, Katsuhiko ;
Kaibuchi, Kozo ;
Inagaki, Shinobu ;
Yamashita, Toshihide .
JOURNAL OF CELL BIOLOGY, 2009, 184 (05) :737-750
[8]   AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease [J].
Ip, Chi Wang ;
Klaus, Laura-Christin ;
Karikari, Akua A. ;
Visanji, Naomi P. ;
Brotchie, Jonathan M. ;
Lang, Anthony E. ;
Volkmann, Jens ;
Koprich, James B. .
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2017, 5 :11
[9]   Identification of the Neogenin-Binding Site on the Repulsive Guidance Molecule A [J].
Itokazu, Takahide ;
Fujita, Yuki ;
Takahashi, Ryosuke ;
Yamashita, Toshihide .
PLOS ONE, 2012, 7 (03)
[10]   Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells [J].
Koch, Jan Christoph ;
Toenges, Lars ;
Michel, Uwe ;
Baehr, Mathias ;
Lingor, Paul .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2014, 8
12