Reversible photoresponsive activity of a carbonic anhydrase mimic

被引：22

作者：

Saha, Monochura ^{[1
]}

Bandyopadhyay, Subhajit ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Kolkata, Dept Chem Sci, Mohanpur 741246, Nadia, India

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 22期

关键词：

SWITCHABLE CATALYSIS; OPTICAL CONTROL; PROTEIN; IMIDAZOLES; HYDRATION; ZINC(II); ENZYMES; LIGAND; MODEL;

D O I：

10.1039/c9cc00018f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The carbonic anhydrase (CA) enzyme reversibly transforms carbon dioxide and water to a carbonate ion and a proton. Photoresponsive enzyme mimics, where the CA-activity can be turned on and off reversibly with light, have not been reported so far. We have designed an active site mimic that offers reversible control of the catalytic activity using light. Moreover, in the presence of a cationic polymer, we have demonstrated that the CA-activity was further enhanced by stabilizing the transition state with the cis-form of the enzyme mimic which can catalyze the hydration of gaseous CO2.

引用

页码：3294 / 3297

页数：4

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