The type 2 capsule locus of Streptococcus pneumoniae

被引：89
作者：
Iannelli, F [1 ]
Pearce, BJ [1 ]
Pozzi, G [1 ]
机构：
[1] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy
来源：
JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 08期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/JB.181.8.2652-2654.1999
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The type 2 capsule locus of Streptococcus pneumoniae was characterized in Avery's strain D39, which is the parent strain of the standard transformation recipients currently used in pneumococcal research and is largely used as a virulent strain in studies on the pathogenesis of pneumococcal infections, The capsule locus was sequenced by using a 21.7-kb PCR fragment from the D39 genome as a template. Sequence data analysis showed the presence of 18 open reading frames, 17 of which have the same direction of transcription and all of which are potentially involved in capsule biosynthesis. It was also shown that R36A and R6, which are unencapsulated (rough) derivatives of D39, carry a 7,504-bp deletion involving nine capsule genes.
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页码：2652 / 2654
页数：3
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