Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies

被引：0
作者：
Aisen, PS
机构：
来源：
GERONTOLOGY | 1997年 / 43卷 / 1-2期
关键词：
Alzheimer's disease; inflammation; anti-inflammatory drugs; glucocorticoids; therapeutics;
D O I：
暂无
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Inflammatory mechanisms in the brain may contribute to the neurodegenerative process in Alzheimer's disease. The cerebral acute-phase response mediated by inflammatory cytokines, the complement cascade, and the accumulation of activated microglial cells are appropriate targets for anti-inflammatory intervention. Pilot studies showed that tolerable doses of prednisone suppress the peripheral acute-phase response in Alzheimer's disease, and a multicenter therapeutic trial of prednisone is in progress. Two other anti-inflammatory drugs, hydroxychloroquine and colchicine, are also under investigation.
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页码：143 / 149
页数：7
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