Synthesis, Spectral Characterisation and Biological Activities of Novel Biomaterial/N, N, O Donor Tridentate Co (II), Ni (II) and Zn (II) Complexes of Hydrazide Based Biopolymer Schiff Base Ligand

In this study novel biopolymer and water soluble O-carboxymethyl chitosan Schiff base derivatives have been designed for potential use in biological applications. Chemically modified O-carboxymethyl chitosan Schiff base and their metal complexes were prepared for potential application in antibacterial, antifungal, anti-inflammatory, total antioxidant, antidiabetic avenues. Chitosan possess water insolubility has been eliminated by carboxymethylation. The thermal decompositions of metal complexes results that the chitosan polymer had more thermal stability than Schiff base ligand and their Co (II), Ni (II) and Zn (II) metal complexes. The antibacterial results showed that the Ni (II) metal complexes had more efficacies against the bacteria and fungi. The anti-inflammatory studies of compounds reveals that the nickel (II) complex was denatured about 91.88 +/- 3.1% of bovine serum albumin (BSA). The biological studies proved that the synthesized compounds possess better antibacterial, antifungal, anti-inflammatory, antidiabetic and antioxidant in nature. [GRAPHICS] .