Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells

被引：18
|
作者：
Slamova, M. [2 ]
Skallova, A. [3 ]
Palenikova, J. [2 ]
Kopecky, J. [1 ]
机构：
[1] Acad Sci Czech Republic, Inst Parasitol, Dept Parasite Immunol, Ctr Biol, CR-37005 Ceske Budejovice, Czech Republic
[2] Univ S Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice, Czech Republic
[3] Charles Univ Prague, Dept Immunol, Sch Med 2, Prague, Czech Republic
来源：
PARASITE IMMUNOLOGY | 2011年 / 33卷 / 12期
关键词：
Borrelia; dendritic cell; immune modulation; Ixodes ricinus; GLAND EXTRACT; IXODES-DAMMINI; LYME BORRELIOSIS; INTERFERON-GAMMA; BURGDORFERI; HOST; EXPRESSION; MATURATION; RESPONSES; HYPORESPONSIVENESS;
D O I：
10.1111/j.1365-3024.2011.01332.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-alpha and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia-DCs interaction.
引用
收藏
页码：654 / 660
页数：7
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