On the relationship between excess body weight, hypertension, hyperinsulinemia and impaired glucose tolerance

Eighty five normoglycemic men aged 20-50 years with body mass index 20,8-39,6 kg/m(2) including 35 men with stage II hypertensive disease (essential hypertension) were investigated. Patients with hypertension had hyperinsulinemia, hypercholesterolemia, hypertriglyceridemia and dyslipidemia. Atherogenic changes in these patients were facilitated by insulin resistance. With this obesity observed in the patients aggravated metabolic disturbances. Relationship of excess body mass with insulin resistance was confirmed by direct correlation between body mass index and level of insulinemia. For assessment of influence of disturbances of lipid metabolism and hypertension on possible development of disturbances of glucose tolerance standard test with glucose loading was carried out in 65 patients. It was noted that discovered impaired glucose tolerance could develop not only in obesity but in a greater degree in hypertension and combined forms of arterial hypertension and excess body mass in metabolic syndrome.