Use of the steroid backbone in the search for a range of compounds as potential inhibitors of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD)

被引:0
|
作者
Soltani-Khankahdani, S. [1 ]
Dhanani, S. [2 ]
Owen, C. P. [1 ]
Ahmed, S. [1 ]
机构
[1] Kingston Univ, Dept Pharm, Sch Chem & Pharmaceut Sci, Kingston, Surrey, England
[2] Kingston Univ, Sch Life Sci, Kingston, Surrey, England
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:S38 / S38
页数:1
相关论文
共 50 条
  • [31] Synthesis and biochemical evaluation of a series of aryl ketones as potent and specific inhibitors of type 3 isozyme of 17β-hydroxysteroid dehydrogenase (17β-HSD)
    Olusanjo, M. S.
    Lota, R.
    Owen, C. P.
    Ahmed, S.
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2007, 59 : A47 - A48
  • [32] Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): The Role of the Bicyclic Moiety
    Oster, Alexander
    Klein, Tobias
    Henn, Claudia
    Werth, Ruth
    Marchais-Oberwinkler, Sandrine
    Frotscher, Martin
    Hartmann, Rolf W.
    CHEMMEDCHEM, 2011, 6 (03) : 476 - 487
  • [33] Synthesis and biochemical evaluation of a series of potential novel inhibitors of 17β-hydroxysteroid dehydrogenase
    Shah, K.
    Olusanjo, M. S.
    Owen, C. P.
    Ahmed, S.
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2009, 61 : A11 - A12
  • [34] The type 2 isozyme of 17β-hydroxysteroid dehydrogenase (17β-HSD) predominates in human sebaceous glands.
    Thiboutot, D
    Martin, P
    Volikas, L
    Gilliland, K
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (04) : 530 - 530
  • [35] Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1)
    He, Wanhong
    Gauri, Misra
    Li, Tang
    Wang, Ruixuan
    Lin, Sheng-Xiang
    GENE, 2016, 588 (01) : 54 - 61
  • [36] Synthesis and biological characterization of a 17β hydroxysteroid dehydrogenase type 10 (17β-HSD10) inhibitor
    Dow, Louise F.
    Pathirage, Rasangi
    Erickson, Helen E.
    Amani, Edrees
    Ronning, Donald R.
    Trippier, Paul C.
    RSC MEDICINAL CHEMISTRY, 2025, 16 (02): : 862 - 875
  • [37] New inhibitors of 17β-hydroxysteroid dehydrogenase type 1
    Messinger, J
    Hirvelä, L
    Husen, B
    Kangas, L
    Koskimies, P
    Pentikäinen, O
    Saarenketo, P
    Thole, H
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 248 (1-2) : 192 - 198
  • [38] Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17β-hydroxysteroid dehydrogenase (17β-HSD type 3):: Further studies with tamoxifen on the rat testes microsomal enzyme
    Le Lain, R
    Barrell, KJ
    Saeed, GS
    Nicholls, PJ
    Simons, C
    Kirby, A
    Smith, HJ
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2002, 17 (02) : 93 - 100
  • [39] Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis
    Wetzel, Marie
    Gargano, Emanuele M.
    Hinsberger, Stefan
    Marchais-Oberwinkler, Sandrine
    Hartmann, Rolf W.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 47 : 1 - 17
  • [40] Introduction of an Electron Withdrawing Group on the Hydroxyphenylnaphthol Scaffold Improves the Potency of 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors
    Wetzel, Marie
    Marchais-Oberwinkler, Sandrine
    Perspicace, Enrico
    Moeller, Gabriele
    Adamski, Jerzy
    Hartmann, Rolf W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (21) : 7547 - 7557