Cytomegalovirus-vectored vaccines for HIV and other pathogens

被引：10

作者：

Barry, Peter A. ^{[1
,2
,3
]}

Deere, Jesse D. ^{[1
,2
,3
]}

Yue, Yujuan ^{[2
]}

Chang, William W. L. ^{[1
,2
,3
]}

Schmidt, Kimberli A. ^{[2
]}

Wussow, Felix ^{[6
]}

Chiuppesi, Flavia ^{[6
]}

Diamond, Don J. ^{[6
]}

Sparger, Ellen E. ^{[4
]}

Walter, Mark R. ^{[7
]}

Hartigan-O'Connor, Dennis J. ^{[3
,5
]}

机构：

[1] Univ Calif Davis, Dept Pathol & Lab Med, Davis, CA 95616 USA

[2] Univ Calif Davis, Ctr Immunol & Infect Dis, Davis, CA 95616 USA

[3] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[4] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA

[5] Univ Calif Davis, Dept Microbiol & Immunol, Sch Med, Davis, CA 95616 USA

[6] City Of Hope, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA

[7] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

AIDS | 2020年 / 34卷 / 03期

关键词：

AIDS; cytomegalovirus; cytomegalovirus vaccine vector; HIV; nonhuman primate; monkey model; rhesus; rhesus cytomegalovirus; simian immunodeficiency virus; unconventional T-cell responses; MAJOR HISTOCOMPATIBILITY COMPLEX; CHEMOKINE RECEPTOR US28; CD8(+) T-CELLS; MHC CLASS-I; MITOCHONDRIA-LOCALIZED INHIBITOR; SIMIAN IMMUNODEFICIENCY VIRUS; RHESUS CYTOMEGALOVIRUS; HLA-E; VIRAL INTERLEUKIN-10; SURFACE EXPRESSION;

D O I：

10.1097/QAD.0000000000002396

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of cytomegalovirus (CMV) as a vaccine vector to express antigens against multiple infectious diseases, including simian immunodeficiency virus, Ebola virus, plasmodium, and mycobacterium tuberculosis, in rhesus macaques has generated extraordinary levels of protective immunity against subsequent pathogenic challenge. Moreover, the mechanisms of immune protection have altered paradigms about viral vector-mediated immunity against ectopically expressed vaccine antigens. Further optimization of CMV-vectored vaccines, particularly as this approach moves to human clinical trials will be augmented by a more complete understanding of how CMV engenders mechanisms of immune protection. This review summarizes the particulars of the specific CMV vaccine vector that has been used to date (rhesus CMV strain 68-1) in relation to CMV natural history.

引用

页码：335 / 349

页数：15

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