Luteal phase support in in vitro fertilization:: Meta-analysis of randomized trials

被引：58

作者：

Nosarka, S ^{[1
]}

Kruger, T ^{[1
]}

Siebert, I ^{[1
]}

Grové, D ^{[1
]}

机构：

[1] Univ Stellenbosch, Dept Obstet & Gynaecol, ZA-7505 Tygerberg, South Africa

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2005年 / 60卷 / 02期

关键词：

luteal phase support; in vitro fertilization; pregnancy rate; meta-analysis;

D O I：

10.1159/000084546

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective:To determine if luteal phase support improves the pregnancy rate in in vitro fertilization (IVF) cycles. Design: A meta-analysis of randomized trials of luteal phase support was carried out with the main outcome measure being the pregnancy rate per cycle. Results: Fifty-nine trials were evaluated. Eighteen trials met the inclusion criteria. Five main themes were identified: human chorionic gonadotropin (hCG) versus progesterone; progesterone versus progesterone and hCG; progesterone versus placebo; hCG versus placebo, and hCG versus progesterone versus no support. Conclusion: Luteal phase support is definitely indicated in IVF treatment cycles. This meta-analysis favored hCG above progesterone as luteal phase support with respect to pregnancy rates. Further prospective randomized trials are needed to determine a definite consensus with respect to the duration of luteal phase support in IVF cycles. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：67 / 74

页数：8

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