Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology
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作者:
Li, Shasha
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Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R ChinaWuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
Li, Shasha
[1
]
Bai, Lei
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Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R ChinaWuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
Bai, Lei
[2
]
Dong, Jiazhen
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Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R ChinaWuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
Dong, Jiazhen
[2
]
Sun, Rui
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Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R ChinaWuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
Sun, Rui
[2
]
Lan, Ke
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Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R ChinaWuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
Lan, Ke
[1
]
机构:
[1] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
[2] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman's disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.