Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology

被引：28
作者：
Li, Shasha [1 ]
Bai, Lei [2 ]
Dong, Jiazhen [2 ]
Sun, Rui [2 ]
Lan, Ke [1 ]
机构：
[1] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
[2] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
来源：
INFECTIOUS AGENTS ASSOCIATED CANCERS: EPIDEMIOLOGY AND MOLECULAR BIOLOGY | 2017年 / 1018卷
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
Kaposi's sarcoma-associated herpesvirus; KSHV life cycle; KSHV epidemiology; KSHV pathogenesis; PROTEIN-COUPLED RECEPTOR; PRIMARY-EFFUSION LYMPHOMA; MICROVASCULAR ENDOTHELIAL-CELLS; FIBROBLAST-GROWTH-FACTOR; LATENT NUCLEAR ANTIGEN; SMALL CAPSID PROTEIN; DE-NOVO INFECTION; SPINDLE CELLS; TARGET-CELLS; GENE-EXPRESSION;
D O I：
10.1007/978-981-10-5765-6_7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman's disease. KSHV manipulates numerous viral proteins to promote the progression of angiogenesis and tumorigenesis. In this chapter, we review the epidemiology and molecular biology of KSHV and the mechanisms underlying KSHV-induced diseases.
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页码：91 / 127
页数：37
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