Dimerizable redox-sensitive triazine-based cationic lipids for in vitro gene delivery

被引：36

作者：

Candiani, Gabriele

Frigerio, Massimo

Viani, Fiorenza

Verpelli, Chiara

Sala, Carlo

Chiamenti, Luca

Zaffaroni, Nadia

Folini, Marco

Sani, Monica

Panzeri, Walter

Zanda, Matteo

机构：

[1] C.N.R. - Istituto di Chimica del Riconoscimento Molecolare, Dipartimento C.M.I.C., Politecnico di Milano, 20131 Milan

[2] C.N.R. - Institute of Neuroscience, Cellular and Molecular Pharmacology, 20129 Milano

[3] Dipartimento di Oncologia Sperimentale, U.O. # 10, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Via Venezian

[4] C.N.R. -Istituto di Chimica del Riconoscimento Molecolare, KemoTech s.r.l., 20131 Milan

来源：

CHEMMEDCHEM | 2007年 / 2卷 / 03期

关键词：

Amphiphiles; DNA; Thiols; Transfection; Triazines;

D O I：

10.1002/cmdc.200600267

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Chemical Equation Presented) The "Trojan Horse" trick works again. Conceptually new melamine-based cationic lipids show excellent transfection efficiency and low cytotoxicity in delivering a DNA plasmid payload to different types of cells, deceiving the natural mechanism of defense toward exogeneous DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：292 / 296

页数：5

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