Asymmetric Michael reactions of α,α-disubstituted aldehydes with maleimides using a primary amine thiourea organocatalyst

被引:42
|
作者
Miura, Tsuyoshi [1 ]
Masuda, Akira [1 ]
Ina, Mariko [1 ]
Nakashima, Kosuke [1 ]
Nishida, Shohei [1 ]
Tada, Norihiro [1 ]
Itoh, Akichika [1 ]
机构
[1] Gifu Pharmaceut Univ, Gifu 5011196, Japan
基金
日本学术振兴会;
关键词
ENANTIOSELECTIVE CONJUGATE ADDITION; ALDOL REACTIONS; GUANIDINE;
D O I
10.1016/j.tetasy.2011.09.006
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Primary amine thiourea organocatalyst 8 was used to promote Michael additions of bulky alpha,alpha-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1605 / 1609
页数:5
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