Asymmetric Michael reactions of α,α-disubstituted aldehydes with maleimides using a primary amine thiourea organocatalyst

被引：42

作者：

Miura, Tsuyoshi ^{[1
]}

Masuda, Akira ^{[1
]}

Ina, Mariko ^{[1
]}

Nakashima, Kosuke ^{[1
]}

Nishida, Shohei ^{[1
]}

Tada, Norihiro ^{[1
]}

Itoh, Akichika ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Gifu 5011196, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 16-17期

基金：

日本学术振兴会;

关键词：

ENANTIOSELECTIVE CONJUGATE ADDITION; ALDOL REACTIONS; GUANIDINE;

D O I：

10.1016/j.tetasy.2011.09.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Primary amine thiourea organocatalyst 8 was used to promote Michael additions of bulky alpha,alpha-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee. (C) 2011 Elsevier Ltd. All rights reserved.

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收藏

页码：1605 / 1609

页数：5

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