The effect of Ginkgo biloba extract (EGb 761) on parameters of oxidative stress in different regions of aging rat brains after acute hypoxia

被引:1
作者
Martin, Rosemarie [1 ]
Mozet, Christian [2 ]
Martin, Hans [1 ]
Welt, Klaus [3 ]
Engel, Christoph [4 ]
Fitzl, Guenther [3 ]
机构
[1] Univ Leipzig, Dept Med, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany
[2] Univ Leipzig, Dept Med, Inst ENT, D-04103 Leipzig, Germany
[3] Univ Leipzig, Dept Med, Inst Anat, D-04103 Leipzig, Germany
[4] Univ Leipzig, Inst Med Informat Stat & Epidemiol IMISE, D-04103 Leipzig, Germany
关键词
Acute hypoxia; aging; brain regions; CK; Ginkgo biloba extract (EGb761); oxidative stress; CREATINE-KINASE ISOENZYMES; PROTEIN OXIDATION; VITAMIN-E; INCREASES; ISCHEMIA; EXERCISE; DAMAGES; ENZYMES; TISSUES; SYSTEM;
D O I
10.1007/BF03337752
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background and aims: Neurodegenerative processes of aging seem to be associated with oxidative stress by reactive oxygen species (ROS). This study investigates the influence of age and of acute respiratoric hypoxia on parameters of oxidative stress in different brain regions of Wistar rats and the protective effects of Ginkgo extract (EGb 761) as a radical scavenger. Methods: Biopsies of frontal and temporal cortices, the cerebellum, and the brainstem of young and old rats (each group n=6-8: normoxic - hypoxic; unprotected - EGb-protected) were analyzed for malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione (GSH) content, and creatine kinase (CK) activity. Experimental hypoxia: down regulation of oxygen partial pressure to 5 vol. % for 20 minutes. EGb administration: daily 100 mg/kg of body weight in drinking water for 3 months. Results: Effects of age: While most oxidative stress parameters in the temporal cortex, the cerebellum, and the brainstem are increased, this is not the case in the frontal cortex; after additional hypoxia SOD and GSH are diminished in the temporal cortex and the brainstem of old rats. EGb treatment causes contradictory alterations in young, old, and hypoxic brain regions. Minor effects are seen in old hypoxic brains, while there are some protective effects in old normoxic brainstems and cerebellums. Conclusions: The old brain appears to adapt appropriately to chronic oxidative stress and to the specific conditions of short-term hypoxia. EGb's protective effect is especially notable in the brainstem and the cerebellum. (Aging Clin Exp Res 2011; 23: 255-263) (C) 2011, Editrice Kurtis
引用
收藏
页码:255 / 263
页数:9
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