Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test

被引：22

作者：

Unger, Marcus M. ^{[1
]}

Moeller, Jens C. ^{[1
]}

Mankel, Katharina ^{[1
]}

Schmittinger, Katrin ^{[1
]}

Eggert, Karla M. ^{[1
]}

Stamelou, Maria ^{[1
]}

Stiasny-Kolster, Karin ^{[1
]}

Bohne, Katharina ^{[3
]}

Bodden, Maren ^{[1
]}

Mayer, Geert ^{[1
,2
]}

Oertel, Wolfgang H. ^{[1
]}

Tebbe, Johannes J. ^{[3
,4
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35043 Marburg, Germany

[2] Hephata Clin Neurol, Dept Neurol, Schwalmstadt, Germany

[3] Univ Marburg, Dept Internal Med, D-35043 Marburg, Germany

[4] Klinikum Lippe, Div Gastroenterol, Dept Internal Med, Detmold, Germany

来源：

MOVEMENT DISORDERS | 2011年 / 26卷 / 14期

关键词：

REM sleep behavior disorder; RBD; Parkinson's disease; PD; gastric emptying; gastric motility; 13C-octanoate breath test; PARKINSONS-DISEASE; REM-SLEEP; TIME;

D O I：

10.1002/mds.23933

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Delayed gastric emptying is a non-motor symptom of Parkinson's disease. Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods: Twenty healthy controls, 13 patients with idiopathic rapid-eye-movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the (13)C-octanoate breath test. Results: Gastric emptying was significantly delayed in drug-naive (P <. 001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid-eye-movement sleep behavior disorder. Conclusions: Our study confirms delayed gastric emptying in drug-naive, early-stage Parkinson's disease. Normal gastric emptying in idiopathic rapid-eye-movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the (13)C-octanoate breath test. (C) 2011 Movement Disorder Society

引用

页码：2559 / 2563

页数：5

共 17 条

[11] Manifestations of Parkinson disease differ in association with REM sleep behavior disorder [J].

Postuma, Ronald B. ;

Gagnon, Jean-Francois ;

Vendette, Melanie ;

Charland, Katia ;

Montplaisir, Jacques .

MOVEMENT DISORDERS, 2008, 23 (12) :1665-1672

[12]

Schenck CH, 2003, SLEEP, V26, pA316

[13] RAPID EYE-MOVEMENT SLEEP BEHAVIOR DISORDER - A TREATABLE PARASOMNIA AFFECTING OLDER ADULTS [J].

SCHENCK, CH ;

BUNDLIE, SR ;

PATTERSON, AL ;

MAHOWALD, MW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (13) :1786-1789

[14] Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for α-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT [J].

Stiasny-Kolster, K ;

Doerr, Y ;

Möller, JC ;

Höffken, H ;

Behr, TM ;

Oertel, WH ;

Mayer, G .

BRAIN, 2005, 128 :126-137

[15] Real-time Visualization of Altered Gastric Motility by Magnetic Resonance Imaging in Patients with Parkinson's Disease [J].

Unger, Marcus M. ;

Hattemer, Katja ;

Moeller, Jens C. ;

Schmittinger, Katrin ;

Mankel, Katharina ;

Eggert, Karla ;

Strauch, Konstantin ;

Tebbe, Johannes J. ;

Keil, Boris ;

Oertel, Wolfgang H. ;

Heverhagen, Johannes T. ;

Knake, Susanne .

MOVEMENT DISORDERS, 2010, 25 (05) :623-628

[16] Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease [J].

Valappil, Ruksana Azhu ;

Black, Jed E. ;

Broderick, Meredith J. ;

Carrillo, Oscar ;

Frenette, Eric ;

Sullivan, Shannon S. ;

Goldman, Samuel M. ;

Tanner, Caroline M. ;

Langston, James W. .

MOVEMENT DISORDERS, 2010, 25 (14) :2296-2303

[17] LEWY BODIES IN THE ENTERIC NERVOUS-SYSTEM IN PARKINSONS-DISEASE [J].

WAKABAYASHI, K ;

TAKAHASHI, H ;

TAKEDA, S ;

OHAMA, E ;

IKUTA, F .

ARCHIVES OF HISTOLOGY AND CYTOLOGY, 1989, 52 :191-194

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