Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test

被引：22

作者：

Unger, Marcus M. ^{[1
]}

Moeller, Jens C. ^{[1
]}

Mankel, Katharina ^{[1
]}

Schmittinger, Katrin ^{[1
]}

Eggert, Karla M. ^{[1
]}

Stamelou, Maria ^{[1
]}

Stiasny-Kolster, Karin ^{[1
]}

Bohne, Katharina ^{[3
]}

Bodden, Maren ^{[1
]}

Mayer, Geert ^{[1
,2
]}

Oertel, Wolfgang H. ^{[1
]}

Tebbe, Johannes J. ^{[3
,4
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35043 Marburg, Germany

[2] Hephata Clin Neurol, Dept Neurol, Schwalmstadt, Germany

[3] Univ Marburg, Dept Internal Med, D-35043 Marburg, Germany

[4] Klinikum Lippe, Div Gastroenterol, Dept Internal Med, Detmold, Germany

来源：

MOVEMENT DISORDERS | 2011年 / 26卷 / 14期

关键词：

REM sleep behavior disorder; RBD; Parkinson's disease; PD; gastric emptying; gastric motility; 13C-octanoate breath test; PARKINSONS-DISEASE; REM-SLEEP; TIME;

D O I：

10.1002/mds.23933

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Delayed gastric emptying is a non-motor symptom of Parkinson's disease. Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods: Twenty healthy controls, 13 patients with idiopathic rapid-eye-movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the (13)C-octanoate breath test. Results: Gastric emptying was significantly delayed in drug-naive (P <. 001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid-eye-movement sleep behavior disorder. Conclusions: Our study confirms delayed gastric emptying in drug-naive, early-stage Parkinson's disease. Normal gastric emptying in idiopathic rapid-eye-movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the (13)C-octanoate breath test. (C) 2011 Movement Disorder Society

引用

页码：2559 / 2563

页数：5

共 17 条

[1] Frequency of bowel movements and the future risk of Parkinson's disease [J].

Abbott, RD ;

Petrovitch, H ;

White, LR ;

Masaki, KH ;

Tanner, CM ;

Curb, JD ;

Grandinetti, A ;

Blanchette, PL ;

Popper, JS ;

Ross, GW .

NEUROLOGY, 2001, 57 (03) :456-462

[2]

[Anonymous], 2005, INT CLASS SLEEP DIS

[3] Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology [J].

Braak, H ;

de Vos, RAI ;

Bohl, J ;

Del Tredici, K .

NEUROSCIENCE LETTERS, 2006, 396 (01) :67-72

[4] Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen [J].

Braak, H ;

Rüb, U ;

Gai, WP ;

Del Tredici, K .

JOURNAL OF NEURAL TRANSMISSION, 2003, 110 (05) :517-536

[5] THE RELEVANCE OF THE LEWY BODY TO THE PATHOGENESIS OF IDIOPATHIC PARKINSONS-DISEASE [J].

GIBB, WRG ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (06) :745-752

[6] Predictors of gastric emptying in Parkinson's disease [J].

Goetze, O ;

Nikodem, AB ;

Wiezcorek, J ;

Banasch, M ;

Przuntek, H ;

Mueller, T ;

Schmidt, WE ;

Woitalla, D .

NEUROGASTROENTEROLOGY AND MOTILITY, 2006, 18 (05) :369-375

[7] Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test [J].

Goetze, O ;

Wieczorek, J ;

Mueller, T ;

Przuntek, H ;

Schmidt, WE ;

Woitalla, D .

NEUROSCIENCE LETTERS, 2005, 375 (03) :170-173

[8] Gastric emptying time and gastric motility in patients with Parkinson's disease [J].

Hardoff, R ;

Sula, M ;

Tamir, A ;

Soil, A ;

Front, A ;

Badarna, S ;

Honigman, S ;

Giladi, N .

MOVEMENT DISORDERS, 2001, 16 (06) :1041-1047

[9] Parkinson's disease: a dual-hit hypothesis [J].

Hawkes, C. H. ;

Del Tredici, K. ;

Braak, H. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2007, 33 (06) :599-614

[10] Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder:: a descriptive study [J].

Iranzo, Alex ;

Molinuevo, Jose Luis ;

Santamaria, Joan ;

Serradell, Monica ;

Marti, Maria Jose ;

Valldeoriola, Francesc ;

Tolosa, Eduard .

LANCET NEUROLOGY, 2006, 5 (07) :572-577

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