Laboratory Investigation of Myeloproliferative Neoplasms (MPNs)

被引：0

作者：

Busque, Lambert ^{[1
]}

Porwit, Anna ^{[2
,3
]}

Day, Radmila ^{[5
]}

Olney, Harold J. ^{[6
]}

Leber, Brian ^{[7
]}

Ethier, Vincent ^{[1
]}

Sirhan, Shireen ^{[8
]}

Foltz, Linda ^{[9
]}

Prchal, Jaroslav ^{[10
]}

Kamel-Reid, Suzanne ^{[2
,3
]}

Karsan, Aly ^{[11
,12
]}

Gupta, Vikas ^{[4
]}

机构：

[1] Univ Montreal, Hop Maisonneuve Rosemont, Dept Lab Hematol, 5415 Blvd Assompt, Montreal, PQ H1T 2M4, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada

[5] Fus MD Med Sci Network, Montreal, PQ, Canada

[6] Ctr Hosp Univ Montreal, Dept Hematol & Transfus Med, Montreal, PQ, Canada

[7] McMaster Univ, Dept Med Hematol & Thromboembolism, Hamilton, ON, Canada

[8] Jewish Gen Hosp, Div Hematol, Montreal, PQ, Canada

[9] Univ British Columbia, St Pauls Hosp, Div Hematol, Vancouver, BC, Canada

[10] McGill Univ, Div Oncol, Montreal, PQ, Canada

[11] BC Canc Agcy, Pathol & Lab Med, Vancouver, BC, Canada

[12] BC Canc Agcy, Michael Smith Genome Sci Ctr, Vancouver, BC, Canada

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2016年 / 146卷 / 04期

关键词：

Myeloproliferative neoplasms; Myelofibrosis; Polycythemia vera; Essential thrombocythemia; JAK2; V617F; CALR; MPL; BCR-ABL negative; EXON; 12; MUTATIONS; ERYTHROID COLONY FORMATION; TYROSINE KINASE JAK2; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; PRIMARY MYELOFIBROSIS; DIAGNOSTIC-CRITERIA; SOMATIC MUTATIONS; CLONAL HEMATOPOIESIS; MOLECULAR DIAGNOSIS;

D O I：

10.1093/AJCP/AQW131

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: To standardize diagnostic investigations for myeloproliferative neoplasms (MPNs) to increase homogeneity in patient care and to streamline diagnostic approaches in the most efficient and cost-effective manner. Methods: The development of Canadian expert consensus recommendations for the diagnosis of MPNs began with a review of the following: clinical evidence, daily practice, existing treatment guidelines, and availability of diagnostic tools. Each group member was assigned a specific topic, which they discussed with the entire group during several consensus meetings. Results: This document provides the Canadian MPN group's recommendations, proposed diagnostic algorithms, and background evidence upon which decisions were made. Conclusions: Standardization of diagnostic investigations will increase homogeneity in patient care and provide a foundation for future clinical research in this rapidly evolving therapeutic area. Streamlining diagnostic approaches in the most efficient and cost-effective manner will also result in significant cost saving for the health care system.

引用

页码：408 / 422

页数：15

共 90 条

[11]

BUDDE U, 1993, BLOOD, V82, P1749

[12] Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis [J].

Busque, Lambert ;

Patel, Jay P. ;

Figueroa, Maria E. ;

Vasanthakumar, Aparna ;

Provost, Sylvie ;

Hamilou, Zineb ;

Mollica, Luigina ;

Li, Juan ;

Viale, Agnes ;

Heguy, Adriana ;

Hassimi, Maryam ;

Socci, Nicholas ;

Bhatt, Parva K. ;

Gonen, Mithat ;

Mason, Christopher E. ;

Melnick, Ari ;

Godley, Lucy A. ;

Brennan, Cameron W. ;

Abdel-Wahab, Omar ;

Levine, Ross L. .

NATURE GENETICS, 2012, 44 (11) :1179-1181

[13] Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients [J].

Cabagnols, Xenia ;

Favale, Fabrizia ;

Pasquier, Florence ;

Messaoudi, Kahia ;

Defour, Jean Philippe ;

Ianotto, Jean Christophe ;

Marzac, Christophe ;

Le Couedic, Jean Pierre ;

Droin, Nathalie ;

Chachoua, Ilyas ;

Favier, Remi ;

Diop, M'boyba Khadija ;

Ugo, Valerie ;

Casadevall, Nicole ;

Debili, Najet ;

Raslova, Hana ;

Bellanne-Chantelot, Christine ;

Constantinescu, Stefan N. ;

Bluteau, Olivier ;

Plo, Isabelle ;

Vainchenker, William .

BLOOD, 2016, 127 (03) :333-342

[14]

Campbell PJ, J OLIN ONCOL

[15]

Campregher P, 2014, BLOOD, V124, P4589

[16] Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients [J].

Caramazza, D. ;

Begna, K. H. ;

Gangat, N. ;

Vaidya, R. ;

Siragusa, S. ;

Van Dyke, D. L. ;

Hanson, C. ;

Pardanani, A. ;

Tefferi, A. .

LEUKEMIA, 2011, 25 (01) :82-88

[17] Somatic mutations of JAK2 exon 12 as a molecular basis of erythrocytosis [J].

Cazzola, Mario .

HAEMATOLOGICA, 2007, 92 (12) :1585-+

[18]

Ciaudo M, 1998, HEMATOL CELL THER, V40, P171

[19] Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms [J].

Feenstra, Jelena D. Milosevic ;

Nivarthi, Harini ;

Gisslinger, Heinz ;

Leroy, Emilie ;

Rumi, Elisa ;

Chachoua, Ilyas ;

Bagienski, Klaudia ;

Kubesova, Blanka ;

Pietra, Daniela ;

Gisslinger, Bettina ;

Milanesi, Chiara ;

Jaeger, Roland ;

Chen, Doris ;

Berg, Tiina ;

Schalling, Martin ;

Schuster, Michael ;

Bock, Christoph ;

Constantinescu, Stefan N. ;

Cazzola, Mario ;

Kralovics, Robert .

BLOOD, 2016, 127 (03) :325-332

[20] DIPSS Plus: A Refined Dynamic International Prognostic Scoring System for Primary Myelofibrosis That Incorporates Prognostic Information From Karyotype, Platelet Count, and Transfusion Status [J].

Gangat, Naseema ;

Caramazza, Domenica ;

Vaidya, Rakhee ;

George, Geeta ;

Begna, Kebede ;

Schwager, Susan ;

Van Dyke, Daniel ;

Hanson, Curtis ;

Wu, Wenting ;

Pardanani, Animesh ;

Cervantes, Francisco ;

Passamonti, Francesco ;

Tefferi, Ayalew .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (04) :392-397

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