Laboratory Investigation of Myeloproliferative Neoplasms (MPNs)

被引：0

作者：

Busque, Lambert ^{[1
]}

Porwit, Anna ^{[2
,3
]}

Day, Radmila ^{[5
]}

Olney, Harold J. ^{[6
]}

Leber, Brian ^{[7
]}

Ethier, Vincent ^{[1
]}

Sirhan, Shireen ^{[8
]}

Foltz, Linda ^{[9
]}

Prchal, Jaroslav ^{[10
]}

Kamel-Reid, Suzanne ^{[2
,3
]}

Karsan, Aly ^{[11
,12
]}

Gupta, Vikas ^{[4
]}

机构：

[1] Univ Montreal, Hop Maisonneuve Rosemont, Dept Lab Hematol, 5415 Blvd Assompt, Montreal, PQ H1T 2M4, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada

[5] Fus MD Med Sci Network, Montreal, PQ, Canada

[6] Ctr Hosp Univ Montreal, Dept Hematol & Transfus Med, Montreal, PQ, Canada

[7] McMaster Univ, Dept Med Hematol & Thromboembolism, Hamilton, ON, Canada

[8] Jewish Gen Hosp, Div Hematol, Montreal, PQ, Canada

[9] Univ British Columbia, St Pauls Hosp, Div Hematol, Vancouver, BC, Canada

[10] McGill Univ, Div Oncol, Montreal, PQ, Canada

[11] BC Canc Agcy, Pathol & Lab Med, Vancouver, BC, Canada

[12] BC Canc Agcy, Michael Smith Genome Sci Ctr, Vancouver, BC, Canada

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2016年 / 146卷 / 04期

关键词：

Myeloproliferative neoplasms; Myelofibrosis; Polycythemia vera; Essential thrombocythemia; JAK2; V617F; CALR; MPL; BCR-ABL negative; EXON; 12; MUTATIONS; ERYTHROID COLONY FORMATION; TYROSINE KINASE JAK2; POLYCYTHEMIA-VERA; ESSENTIAL THROMBOCYTHEMIA; PRIMARY MYELOFIBROSIS; DIAGNOSTIC-CRITERIA; SOMATIC MUTATIONS; CLONAL HEMATOPOIESIS; MOLECULAR DIAGNOSIS;

D O I：

10.1093/AJCP/AQW131

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: To standardize diagnostic investigations for myeloproliferative neoplasms (MPNs) to increase homogeneity in patient care and to streamline diagnostic approaches in the most efficient and cost-effective manner. Methods: The development of Canadian expert consensus recommendations for the diagnosis of MPNs began with a review of the following: clinical evidence, daily practice, existing treatment guidelines, and availability of diagnostic tools. Each group member was assigned a specific topic, which they discussed with the entire group during several consensus meetings. Results: This document provides the Canadian MPN group's recommendations, proposed diagnostic algorithms, and background evidence upon which decisions were made. Conclusions: Standardization of diagnostic investigations will increase homogeneity in patient care and provide a foundation for future clinical research in this rapidly evolving therapeutic area. Streamlining diagnostic approaches in the most efficient and cost-effective manner will also result in significant cost saving for the health care system.

引用

页码：408 / 422

页数：15

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