Inhaled Nitric Oxide and Inhaled Prostacyclin in Acute Respiratory Distress Syndrome: What is the Evidence?

被引：20

作者：

Puri, Nitin ^{[1
]}

Dellinger, Richard Phillip ^{[2
]}

机构：

[1] Cooper Univ Hosp, Robert Wood Johnson Med Sch, Dept Med, Div Pulm & Crit Care Med, Camden, NJ 08103 USA

[2] Cooper Univ Hosp, Dept Med, Div Crit Care Med, Camden, NJ 08103 USA

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 03期

关键词：

Acute respiratory distress syndrome; Inhaled nitric oxide; Inhaled prostacyclin; ACUTE LUNG INJURY; FREQUENCY OSCILLATORY VENTILATION; SELECTIVE PULMONARY VASODILATION; AEROSOLIZED PROSTACYCLIN; DOSE-RESPONSE; PROSTAGLANDIN E-1; GAS-EXCHANGE; INHALATION; HYPERTENSION; OXYGENATION;

D O I：

10.1016/j.ccc.2011.05.001

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The mortality for acute respiratory distress syndrome remains unacceptably high. Two vasodilators, inhaled prostacyclin and inhaled nitric oxide, are reviewed in this article. Knowledge of inhaled prostacyclin has grown substantially in the past 30 years, but less research exists about its utility in acute respiratory distress syndrome. Inhaled prostacyclin and other prostaglandin derivatives are used in acute respiratory distress syndrome with increasing frequency. Currently, only randomized controlled trials exist for inhaled nitric oxide in acute respiratory distress syndrome patients. Randomized controlled trials with consistent dosing methods are needed for both vasodilators to better define their role in the treatment of acute respiratory distress syndrome.

引用

页码：561 / +

页数：28

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