Palladium-Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five-Component Coupling Reaction

被引：39

作者：

Bontemps, Sebastien ^{[1
,2
]}

Quesnel, Jeffrey S. ^{[1
,2
]}

Worrall, Kraig ^{[1
,2
]}

Arndtsen, Bruce A. ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

[2] Univ Toulouse, UPS, INPT, F-31077 Toulouse, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 38期

基金：

加拿大自然科学与工程研究理事会;

关键词：

carbonylation; cyclizations; heterocycles; multicomponent reactions; palladium; AMINO-ACID DERIVATIVES; AMIDE BOND FORMATION; MULTICOMPONENT SYNTHESIS; CARBON-MONOXIDE; ENANTIOPURE IMIDAZOLINES; ATMOSPHERIC-PRESSURE; N-SULFONYLIMINES; VINYLIC HALIDES; BETA-LACTAMS; 2-IMIDAZOLINES;

D O I：

10.1002/anie.201103885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Take five: A new method employing aryl halide carbonylation to directly access heterocycles has been described (see scheme). In a single palladium-catalyzed reaction the catalyst mediates two consecutive carbonylation steps, thereby converting five components (aryl iodide, two units imine, and two units CO) into an imidazoline ring. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8948 / 8951

页数：4

共 80 条

[1]

[Anonymous], 2008, ANGEW CHEM INT ED, DOI DOI 10.1002/ANGE.200801385

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