Unexpected high density of neuropeptide Y Y-1 receptors in the guinea pig spleen

被引：4
作者：
Gehlert, DR
Gackenheimer, SL
机构：
[1] CNS Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis
[2] Mail Code 0510, CNS Research, Lilly Research Laboratories, Indianapolis
来源：
PEPTIDES | 1996年 / 17卷 / 08期
关键词：
neuropeptide Y; Y-1; receptors; guinea pig spleen;
D O I：
10.1016/S0196-9781(96)00228-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Receptors for neuropeptide Y (NPY) and peptide YY (PYY) have been extensively characterized in the brain. Less is known about NPY receptor subtypes in the spleen, though it is well established that NPY produces vascular contraction in this tissue. In the present study, we found an unusually high density of Y-1 receptors in the guinea pig spleen. These receptors are localized to the red pulp and exhibit a pharmacology that is consistent with the Y-1 receptor. On the other hand, only very low densities for Y-1 receptors were observed. Therefore, the guinea pig spleen may be a ideal tissue for further study of the role of Y-1 receptors in cardiovascular and immune function. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码：1345 / 1348
页数：4
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