Palladium-catalyzed 1,4-addition of diarylphosphines to α,β-unsaturated N-acylpyrroles

被引：66

作者：

Du, Dan ^{[2
]}

Duan, Wei-Liang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 39期

关键词：

P-STEREOGENIC PHOSPHINES; ORGANOCATALYTIC ASYMMETRIC HYDROPHOSPHINATION; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CHIROGENIC PHOSPHINE; SECONDARY PHOSPHINES; CONJUGATE ADDITION; DIPHENYL PHOSPHITE; ACTIVATED OLEFINS; CHIRAL PHOSPHINES;

D O I：

10.1039/c1cc13785a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly stereoselective asymmetric 1,4-addition of diarylphosphines to alpha,beta-unsaturated N-acylpyrroles catalyzed by a PCP pincer-Pd complex has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (91-99% ee) under mild conditions. The products obtained can be further converted into chiral phosphine-oxazoline ligands.

引用

页码：11101 / 11103

页数：3

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