Palladium-catalyzed 1,4-addition of diarylphosphines to α,β-unsaturated N-acylpyrroles

被引：65
|
作者：
Du, Dan [2 ]
Duan, Wei-Liang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 39期
关键词：
P-STEREOGENIC PHOSPHINES; ORGANOCATALYTIC ASYMMETRIC HYDROPHOSPHINATION; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; CHIROGENIC PHOSPHINE; SECONDARY PHOSPHINES; CONJUGATE ADDITION; DIPHENYL PHOSPHITE; ACTIVATED OLEFINS; CHIRAL PHOSPHINES;
D O I：
10.1039/c1cc13785a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly stereoselective asymmetric 1,4-addition of diarylphosphines to alpha,beta-unsaturated N-acylpyrroles catalyzed by a PCP pincer-Pd complex has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (91-99% ee) under mild conditions. The products obtained can be further converted into chiral phosphine-oxazoline ligands.
引用
收藏
页码：11101 / 11103
页数：3
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