Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

被引：146

作者：

Shi, Jinjun ^{[1
,2
]}

Xiao, Zeyu ^{[1
,2
]}

Votruba, Alexander R. ^{[1
]}

Vilos, Cristian ^{[1
]}

Farokhzad, Omid C. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Anesthesiol, Lab Nanomed & Biomat, Boston, MA 02115 USA

[2] MIT, MIT Harvard Ctr Canc Nanotechnol Excellence, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期

基金：

美国国家卫生研究院;

关键词：

lipids; nanoparticles; polymers; siRNA delivery; TARGETED DELIVERY; DRUG-DELIVERY; IN-VIVO; SIRNA; NANOTECHNOLOGY;

D O I：

10.1002/anie.201101554

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid-polymer-lipid nanostructure is elucidated by electron and fluorescence microscopy (right) and provides the delivery system with distinct functional features. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7027 / 7031

页数：5

共 31 条

[1] A combinatorial library of lipid-like materials for delivery of RNAi therapeutics [J].

Akinc, Akin ;

Zumbuehl, Andreas ;

Goldberg, Michael ;

Leshchiner, Elizaveta S. ;

Busini, Valentina ;

Hossain, Naushad ;

Bacallado, Sergio A. ;

Nguyen, David N. ;

Fuller, Jason ;

Alvarez, Rene ;

Borodovsky, Anna ;

Borland, Todd ;

Constien, Rainer ;

de Fougerolles, Antonin ;

Dorkin, J. Robert ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

John, Matthias ;

Koteliansky, Victor ;

Manoharan, Muthiah ;

Nechev, Lubomir ;

Qin, June ;

Racie, Timothy ;

Raitcheva, Denitza ;

Rajeev, Kallanthottathil G. ;

Sah, Dinah W. Y. ;

Soutschek, Juergen ;

Toudjarska, Ivanka ;

Vornlocher, Hans-Peter ;

Zimmermann, Tracy S. ;

Langer, Robert ;

Anderson, Daniel G. .

NATURE BIOTECHNOLOGY, 2008, 26 (05) :561-569

[2] Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes [J].

Auguste, Debra T. ;

Furman, Kay ;

Wong, Andrew ;

Fuller, Jason ;

Armes, Steven P. ;

Deming, Timothy J. ;

Langer, Robert .

JOURNAL OF CONTROLLED RELEASE, 2008, 130 (03) :266-274

[3] Progress towards in vivo use of siRNAs [J].

Behlke, MA .

MOLECULAR THERAPY, 2006, 13 (04) :644-670

[4] Polymer-supported lipid shells, onions, and flowers [J].

Bershteyn, Anna ;

Chaparro, Jose ;

Yau, Richard ;

Kim, Mikyung ;

Reinherz, Ellis ;

Ferreira-Moita, Luis ;

Irvine, Darrell J. .

SOFT MATTER, 2008, 4 (09) :1787-1791

[5] Delivering the future [J].

Blow, Nathan .

NATURE, 2007, 450 (7172) :1117-1122

[6] The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic [J].

Davis, Mark E. .

MOLECULAR PHARMACEUTICS, 2009, 6 (03) :659-668

[7] Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells [J].

Elbashir, SM ;

Harborth, J ;

Lendeckel, W ;

Yalcin, A ;

Weber, K ;

Tuschl, T .

NATURE, 2001, 411 (6836) :494-498

[8] Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo [J].

Farokhzad, OC ;

Cheng, JJ ;

Teply, BA ;

Sherifi, I ;

Jon, S ;

Kantoff, PW ;

Richie, JP ;

Langer, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (16) :6315-6320

[9] Impact of Nanotechnology on Drug Delivery [J].

Farokhzad, Omid C. ;

Langer, Robert .

ACS NANO, 2009, 3 (01) :16-20

[10] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

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