Inversion of enantioselectivity during the platinum-catalyzed hydrogenation of an activated ketone

被引：0
|
作者：
von Arx, M [1 ]
Mallat, T [1 ]
Baiker, A [1 ]
机构：
[1] ETH Zentrum, Tech Chem Lab, CH-8092 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 12期
关键词：
asymmetric hydrogenation; chiral auxiliaries; heterogeneous catalysis; hydrates; platinum;
D O I：
10.1002/1521-3773(20010618)40:12<2302::AID-ANIE2302>3.0.CO;2-P
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two competing reaction pathways, which lead to opposite enantiomers (see scheme), occur in the hydrogenation of 1 over chirally modified platinum, as revealed by catalytic and NMR spectroscopic experiments: the fast reduction of the ketoform 1a (minor species) and the slow hydrogenolysis of the hydrate 3 (major species).
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页码：2302 / +
页数：5
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