Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis

被引：132

作者：

Damsky, William ^{[1
,2
]}

Thakral, Durga ^{[1
]}

Emeagwali, Nkiruka ^{[4
]}

Galan, Anjela ^{[1
,3
]}

King, Brett ^{[1
]}

机构：

[1] Yale Sch Med, Dept Dermatol, 333 Cedar St,LCI 501,POB 208059, New Haven, CT 06520 USA

[2] Yale Sch Med, Dept Immunobiol, New Haven, CT USA

[3] Yale Sch Med, Dept Pathol, New Haven, CT USA

[4] Yale Sch Med, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 26期

基金：

美国国家卫生研究院;

关键词：

ALVEOLAR MACROPHAGES; GRANULOMA-FORMATION; HELPER;

D O I：

10.1056/NEJMoa1805958

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is evidence that Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling plays a role in the pathogenesis of sarcoidosis. We treated a patient with cutaneous sarcoidosis with the JAK inhibitor tofacitinib; the patient had not previously had a response to medications and had not received systemic glucocorticoids. This treatment resulted in clinical and histologic remission of her skin disease. Sequencing of RNA and immunohistochemical examination of skin-lesion samples obtained from the patient before and during therapy and immunohistochemical testing of lesion samples obtained from other patients with cutaneous sarcoidosis support a role for JAK-STAT signaling in cutaneous sarcoidosis.

引用

页码：2540 / 2546

页数：7

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