Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines

被引:30
|
作者
Wright, Brian D. [1 ]
Deblock, Michael C. [1 ]
Wagers, Patrick O. [1 ]
Duah, Ernest [1 ]
Robishaw, Nikki K. [1 ]
Shelton, Kerri L. [1 ]
Southerland, Marie R. [1 ]
DeBord, Michael A. [1 ]
Kersten, Kortney M. [1 ]
McDonald, Lucas J. [1 ]
Stiel, Jason A. [1 ]
Panzner, Matthew J. [1 ]
Tessier, Claire A. [1 ]
Paruchuri, Sailaja [1 ]
Youngs, Wiley J. [1 ]
机构
[1] Univ Akron, Dept Chem, Akron, OH 44325 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Imidazolium cation; Imidazolium salt; Anti-tumor; Anticancer; Apoptosis; SILVER CARBENE COMPLEXES; STRUCTURAL CHARACTERIZATION; CISPLATIN;
D O I
10.1007/s00044-015-1330-z
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-small-cell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.
引用
收藏
页码:2838 / 2861
页数:24
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