Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines

被引：30

作者：

Wright, Brian D. ^{[1
]}

Deblock, Michael C. ^{[1
]}

Wagers, Patrick O. ^{[1
]}

Duah, Ernest ^{[1
]}

Robishaw, Nikki K. ^{[1
]}

Shelton, Kerri L. ^{[1
]}

Southerland, Marie R. ^{[1
]}

DeBord, Michael A. ^{[1
]}

Kersten, Kortney M. ^{[1
]}

McDonald, Lucas J. ^{[1
]}

Stiel, Jason A. ^{[1
]}

Panzner, Matthew J. ^{[1
]}

Tessier, Claire A. ^{[1
]}

Paruchuri, Sailaja ^{[1
]}

Youngs, Wiley J. ^{[1
]}

机构：

[1] Univ Akron, Dept Chem, Akron, OH 44325 USA

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Imidazolium cation; Imidazolium salt; Anti-tumor; Anticancer; Apoptosis; SILVER CARBENE COMPLEXES; STRUCTURAL CHARACTERIZATION; CISPLATIN;

D O I：

10.1007/s00044-015-1330-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-small-cell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.

引用

页码：2838 / 2861

页数：24

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