Oral lichen planus: controversies surrounding malignant transformation

被引：221
作者：
Gonzalez-Moles, M. A. [2 ]
Scully, C. [3 ]
Gil-Montoya, J. A. [1 ]
机构：
[1] Univ Granada, Special Care Dent Dept, Fac Dent, E-18071 Granada, Spain
[2] Univ Granada, Dept Oral Med, Fac Dent, E-18071 Granada, Spain
[3] Eastmant Dent Inst, London, England
来源：
ORAL DISEASES | 2008年 / 14卷 / 03期
关键词：
oral lichen planus; malignant transformation; oral cancer;
D O I：
10.1111/j.1601-0825.2008.01441.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure the early diagnosis of transformation. Consensus remains elusive, and leading workers in this field have recently published conflicting reports on the malignant potential of OLP and on the important question of the advisability of excluding patients with epithelial dysplasia or a tobacco habit from studies on this issue. The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease.
引用
收藏
页码：229 / 243
页数：15
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