Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones

被引：3
|
作者：
Khramtsova, Ekaterina E. [1 ]
Lystsova, Ekaterina A. [1 ]
Khokhlova, Evgeniya V. [1 ]
Dmitriev, Maksim V. [1 ]
Maslivets, Andrey N. [1 ]
机构：
[1] Perm State Univ, Dept Chem, Ul Bukireva 15, Perm 614990, Russia
来源：
MOLECULES | 2021年 / 26卷 / 23期
基金：
俄罗斯科学基金会;
关键词：
amination; carbodiimide; pyrrole-2-one; thermolysis; urea; INHIBITORS; DERIVATIVES; DISCOVERY;
D O I：
10.3390/molecules26237179
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biological effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposition of 1,3-disubstituted urea derivatives of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, which were prepared via their reaction with carbodiimides.
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页数：16
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