Simplexins J-O, Eunicellin-Based Diterpenoids from a Dongsha Atoll Soft Coral Klyxum simplex

被引：16

作者：

Wu, Shwu-Li ^{[1
,2
]}

Su, Jui-Hsin ^{[3
,4
]}

Lu, Yi ^{[1
]}

Chen, Bo-Wei ^{[1
]}

Huang, Chiung-Yao ^{[1
]}

Wen, Zhi-Hong ^{[1
]}

Kuo, Yao-Haur ^{[5
]}

Sheu, Jyh-Horng ^{[1
,6
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Kaohsiung Marine Univ, Ctr Gen Studies, Kaohsiung 811, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Checheng 944, Pingtung, Taiwan

[4] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Checheng 944, Pingtung, Taiwan

[5] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2011年 / 84卷 / 06期

关键词：

TUMOR-CELL-LINES; PACHYCLAVULARIA-VIOLACEA; ASSAY;

D O I：

10.1246/bcsj.20110013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six new eunicellin-based diterpenoids, simplexins J-O (1-6), were isolated from a Dongsha Atoll soft coral, Klyxum simplex. The structures of these compounds were established by detailed spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 4-6 have been found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.

引用

页码：626 / 632

页数：7

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