Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives

被引：14

作者：

Santos-Pardo, Irene ^{[1
]}

Villuendas, Roger ^{[1
]}

Salvador-Corres, Inaki ^{[2
]}

Martinez-Morillo, Melania ^{[3
]}

Olive, Alejandro ^{[3
,4
]}

Bayes-Genis, Antoni ^{[1
,4
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Serv Cardiol, E-08193 Barcelona, Spain

[2] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, FOCIS CE, Serv Immunol, E-08193 Barcelona, Spain

[3] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Rheumatol Serv, E-08193 Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2015年 / 184卷

关键词：

Anti-Ro/SSA; Pathogenesis; Cardiac rhythm disturbances; COMPLETE HEART-BLOCK; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CORRECTED QT INTERVAL; SJOGRENS-SYNDROME; ATRIOVENTRICULAR-BLOCK; CONDUCTION DEFECTS; SSB/LA ANTIBODIES; RO ANTIBODIES; SS-A/RO; ADULT;

D O I：

10.1016/j.ijcard.2014.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies. (C) 2014 Published by Elsevier Ireland Ltd.

引用

页码：244 / 250

页数：7

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