Nogo receptor antagonizes p75NTR-dependent motor neuron death

被引：30

作者：

Dupuis, Luc ^{[1
,3
]}

Pehar, Mariana ^{[2
]}

Cassina, Patricia ^{[4
]}

Rene, Frederique ^{[1
,3
]}

Castellanos, Raquel ^{[4
]}

Rouaux, Caroline ^{[1
,3
]}

Gandelman, Mandi ^{[2
]}

Dimou, Leda ^{[5
,6
]}

Schwab, Martin E. ^{[5
,6
]}

Loeffler, Jean-Philippe ^{[1
,3
]}

Barbeito, Luis ^{[2
]}

de Aguilar, Jose-Luis Gonzalez ^{[1
,3
]}

机构：

[1] INSERM, U692, Lab Signalisat Mol & Neurodegenerescence, F-67085 Strasbourg, France

[2] Inst Pasteur, Montevideo 11600, Uruguay

[3] Univ Strasbourg 1, Fac Med, UMRS692, F-67085 Strasbourg, France

[4] Uni Republ, Fac Med, Strasbourg 11800, France

[5] Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland

[6] ETH, Dept Biol, CH-8057 Zurich, Switzerland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 02期

关键词：

NGF; NgR; amyotrophic lateral sclerosis; axotomy; reticulon;

D O I：

10.1073/pnas.0703842105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

引用

页码：740 / 745

页数：6

共 39 条

[1] Expression pattern of NOGO and NgR genes during human development [J].