Investigating the Roles of Platelet PAR4 in Hemostasis, Thrombosis and Viral Infection Using a Newly Generated PAR4 Floxed Mouse

被引：1
|
作者：
Lee, Robert H. [1 ]
Kawano, Tomohiro [2 ]
Bharathi, Vanthana [2 ]
Martinez, David [2 ]
Cowley, Dale O. [3 ]
Grover, Steven P. [2 ]
Mackman, Nigel [4 ]
Bergmeier, Wolfgang [1 ]
Antoniak, Silvio [5 ]
机构：
[1] Univ N Carolina, UNC Blood Res Ctr, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, UNC Blood Res Ctr, Dept Med, Chapel Hill, NC 27515 USA
[3] Univ N Carolina, UNC Anim Models Core, Chapel Hill, NC 27515 USA
[4] Univ N Carolina, Dept Med, UNC Blood Res Ctr, Div Hematol, Chapel Hill, NC 27515 USA
[5] Univ N Carolina, Dept Pathol & Lab Med, UNC Blood Res Ctr, Chapel Hill, NC 27515 USA
来源：
BLOOD | 2021年 / 138卷
关键词：
D O I：
10.1182/blood-2021-151121
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1000
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Human PAR4 Is a More Potent Receptor for Activating Platelets Than Mouse PAR4
    Renna, Stephanie
    Edelstein, Leonard C.
    McKenzie, Steven Edward
    BLOOD, 2019, 134
  • [2] Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
    Vandendries, Erik R.
    Hamilton, Justin R.
    Coughlin, Shaun R.
    Furie, Bruce
    Furie, Barbara C.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) : 288 - 292
  • [3] Pharmacogenocis of PAR4: PAR4 Polymorphism Determines Platelet Response in the Presence of Dual Anti-Platelet Therapy
    Tourdot, Benjamin
    Bray, Paul F.
    Edelstein, Leonard C.
    Holinstat, Michael
    BLOOD, 2015, 126 (23)
  • [4] Platelet responsiveness to PAR4 activation in a healthy population and its inhibition by a potent and selective PAR4 antagonist
    Downes, K.
    Astle, W.
    McKinney, H.
    Kempster, C.
    Batista, J.
    Garner, S.
    Allegretto, N.
    Ouwehand, W. H.
    Yang, J.
    EUROPEAN HEART JOURNAL, 2016, 37 : 1017 - 1017
  • [5] Effect of PAR1 and PAR4 agonists on platelet activity
    Buryachkovskaya, L., I
    Strukova, S. M.
    Uchitel, I. A.
    Sumarokov, A. B.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 781 - 781
  • [6] The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese
    Morikawa, Yoichiro
    Kato, Hisashi
    Akuta, Keigo
    Kashiwagi, Hirokazu
    Honda, Shigenori
    Kanakura, Yuzuru
    Tomiyama, Yoshiaki
    BLOOD, 2016, 128 (22)
  • [7] Platelet thrombin receptors PAR1 and PAR4 act in a synergistic manner
    Oberg, K., V
    Kulsum, S.
    Boknas, N.
    Ramstrom, S.
    Lindahl, T. L.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 629 - 629
  • [8] Visual servoing of par4 using leg observation
    Dallej, Tej
    Andreff, Nicolas
    Martinet, Philippe
    IECON 2006 - 32ND ANNUAL CONFERENCE ON IEEE INDUSTRIAL ELECTRONICS, VOLS 1-11, 2006, : 736 - +
  • [9] PAR1, but not PAR4, regulates human platelet activation through PLD
    Holinstat, M
    Voss, B
    Bilodeau, ML
    Hamm, HE
    FASEB JOURNAL, 2006, 20 (04) : A695 - A696
  • [10] PAR4 Ala120Thr Variant Alters PAR4 Desensitization, Sensitivity to Platelet Antagonists and Risk of Large Vessel Stroke
    Whitley, Michael
    Henke, David
    Simon, Lukas
    Vesci, Joanne
    Holinstat, Michael
    Nieman, Marvin
    Shaw, Chad
    Bray, Paul
    Edelstein, Leonard
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38
12345