Retinal pigment epithelium melanin distribution estimated by polarisation entropy and its association with retinal sensitivity in patients with high myopia

被引:6
作者
Harimoto, Akira [1 ]
Obata, Ryo [1 ]
Yamamoto, Motoshi [1 ]
Aoki, Nobuyori [2 ]
Yamanari, Masahiro [2 ]
Sugiyama, Satoshi [2 ]
Kitano, Marie [1 ]
Fujita, Asahi [1 ]
Minami, Takahiro [1 ]
Ueda, Kohei [1 ]
Azuma, Keiko [1 ]
Inoue, Tatsuya [3 ]
Aihara, Makoto [1 ]
Kato, Satoshi [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo, Japan
[2] Tomey Corp, Engn Dept, Nagoya, Aichi, Japan
[3] Yokohama City Univ, Dept Ophthalmol & Microtechnol, Yokohama, Kanagawa, Japan
关键词
imaging; macula; pathology; retina; choroid; OPTICAL COHERENCE TOMOGRAPHY; IN-VIVO; CHOROIDAL THICKNESS; JONES-MATRIX; CLASSIFICATION; PREVALENCE; BLINDNESS; ADULTS;
D O I
10.1136/bjophthalmol-2021-318890
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose To investigate retinal sensitivity of highly myopic eyes without choroidal neovascularisation (CNV) or patchy chorioretinal atrophy (PCA) and investigated its association with anatomical characteristics including melanin distribution at the retinal pigment epithelium (RPE), which was evaluated with polarisation-sensitive optical coherence tomography (PS-OCT). Design Retrospective consecutive observational cohort study. Methods We included highly myopic eyes (refractive error <=-8.0 dioptres or axial length of >= 26.5 mm) from patients at the University of Tokyo Hospital. Retinal sensitivity was measured by microperimetry at 25 sectors within 6 degrees from the fovea. Depolarisation value, which reflected melanin pigmentation, was measured by a clinical prototype of PS-OCT and was parameterised as polarimetric entropy. Retinal sensitivity or entropy at the RPE in high myopia was compared with emmetropic control subjects. The association of retinal sensitivity with age, axial length, entropy, or choroidal thickness was assessed in per-eye and per-sector analysis. Results Twenty-three highly myopic eyes (age, 66.6 +/- 12.3 years) were included. The average retinal sensitivity was 25.3 +/- 3.0 dB, which was significantly decreased compared with the control (p<0.0001). The average entropy at the RPE in the highly myopic eyes was significantly lower than in the control (p<0.0001). Univariate analysis followed by multivariate analysis showed that besides age, axial length or choroidal thickness, RPE entropy was independently associated with retinal sensitivity (beta=4.4; 95% CI 0.5 to 8.3; p=0.03). Conclusions Decreased depolarisation at the RPE measured with PS-OCT, which reflected altered melanin pigmentation, was independently associated with reduced retinal sensitivity in patients with early stages of myopic maculopathy without CNV or PCA.
引用
收藏
页码:1457 / 1462
页数:6
相关论文
共 34 条
  • [1] INTEROCULAR ASYMMETRY IN CHOROIDAL THICKNESS AND RETINAL SENSITIVITY IN HIGH MYOPIA
    Alzaben, Zeyad
    Cardona, Genis
    Zapata, Miguel A.
    Zaben, Ahmad
    [J]. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2018, 38 (08): : 1620 - 1628
  • [2] Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology
    Baumann, Bernhard
    Schirmer, Johannes
    Rauscher, Sabine
    Fialova, Stanislava
    Gloesmann, Martin
    Augustin, Marco
    Pircher, Michael
    Groeger, Marion
    Hitzenberger, Christoph K.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2015, 56 (12) : 7462 - 7472
  • [3] Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization
    Baumann, Bernhard
    Baumann, Stefan O.
    Konegger, Thomas
    Pircher, Michael
    Goetzinger, Erich
    Schlanitz, Ferdinand
    Schuetze, Christopher
    Sattmann, Harald
    Litschauer, Marco
    Schmidt-Erfurth, Ursula
    Hitzenberger, Christoph K.
    [J]. BIOMEDICAL OPTICS EXPRESS, 2012, 3 (07): : 1670 - 1683
  • [4] Measurements of depolarization distribution in the healthy human macula by polarization sensitive OCT
    Baumann, Bernhard
    Goetzinger, Erich
    Pircher, Michael
    Hitzenberger, Christoph K.
    [J]. JOURNAL OF BIOPHOTONICS, 2009, 2 (6-7) : 426 - 434
  • [5] Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults - The Copenhagen City Eye Study
    Buch, H
    Vinding, T
    la Cour, M
    Appleyard, M
    Jensen, GB
    Nielsen, NV
    [J]. OPHTHALMOLOGY, 2004, 111 (01) : 53 - 61
  • [6] P values are only an index to evidence: 20th-vs. 21st-century statistical science
    Burnham, K. P.
    Anderson, D. R.
    [J]. ECOLOGY, 2014, 95 (03) : 627 - 630
  • [7] OCT-Based Diagnostic Criteria for Different Stages of Myopic Maculopathy
    Fang, Yuxin
    Du, Ran
    Nagaoka, Natsuko
    Yokoi, Tae
    Shinohara, Kosei
    Xu, Xian
    Takahashi, Hiroyuki
    Onishi, Yuka
    Yoshida, Takeshi
    Ohno-Matsui, Kyoko
    [J]. OPHTHALMOLOGY, 2019, 126 (07) : 1018 - 1032
  • [8] The relationship between retinal and choroidal thickness and visual acuity in highly myopic eyes
    Flores-Moreno, Ignacio
    Ruiz-Medrano, Jorge
    Duker, Jay S.
    Ruiz-Moreno, Jose M.
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2013, 97 (08) : 1010 - 1013
  • [9] Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Highly Myopic Eyes
    Fujiwara, Takamitsu
    Imamura, Yutaka
    Margolis, Ron
    Slakter, Jason S.
    Spaide, Richard F.
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2009, 148 (03) : 445 - 450
  • [10] Evaluation of In Vivo Human Retinal Morphology and Function in Myopes
    Gella, Laxmi
    Raman, Rajiv
    Sharma, Tarun
    [J]. CURRENT EYE RESEARCH, 2011, 36 (10) : 943 - 946