Therapeutic Targets In Breast Cancer Signaling: A Review

被引:15
作者
Obeagu, Emmanuel Ifeanyi [1 ]
Babar, Quratulain [2 ]
Vincent, C. C. N. [3 ]
Udenze, Chikwendu Lawrence [4 ]
Eze, Richard [5 ]
Okafor, Chukwuma J. [6 ]
Ifionu, Bart I. [7 ]
Amaeze, Augustine Amaeze [8 ]
Amaeze, Florence Ngozi [9 ]
机构
[1] Imo State Univ, Dept Med Lab Sci, Owerri, Imo State, Nigeria
[2] Govt Coll Univ, Dept Biochem, Faisalabad, Pakistan
[3] Imo State Univ, Dept Nursing Sci, Owerri, Imo State, Nigeria
[4] Michael Okpara Univ Agr, Dept Univ Hlth Serv, Umudike, Abia State, Nigeria
[5] Madonna Univ Elele, Dept Med Lab Sci, Elele, Rivers State, Nigeria
[6] State Univ Zanzibar, Dept Pathol & Biochem, Zanzibar, Tanzania
[7] Olabisi Onabanjo Univ, Dept Chem Pathol & Immunol, Ogun State, Nigeria
[8] Evangel Univ, Dept Physiotherapy, Akaeze, Ebonyi State, Nigeria
[9] Gregory Univ, Dept Publ Hlth Educ, Uturu, Abia State, Nigeria
关键词
Breast cancer; tumor; apoptosis; cell proliferation; AMERICAN SOCIETY; JAK/STAT PATHWAY; IN-VIVO; PROMOTES; ACTIVATION; CELLS; TUMOR; PROLIFERATION; PROGESTERONE; SUPPRESSES;
D O I
10.9734/JPRI/2021/v33i56A33889
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
For women, the most dominant type of cancer is breast cancer and perhaps one of the most recognizedreasons of death. This is a disorder of many distinct traits, many of which are known as positive hormone receptor, human epidermal receptor-2 (HER2+), and three negative breast cancers (TNBC). Drugs that directly target and kill tumors constitute a rapidly-growing form of molecular therapy for cancer patients. Analysis reveals that stable breast tissue cells exhibit receptors which aren't usually present. As a result, it is imperative to cognize the molecular roots of breast cancer and the myriad compromised pathology-related processes and pathways to ensure progresses in early diagnosis and prevention. This study demonstrates essential cellular pathways relevant for breast cancer including improvements in cell proliferation, apoptosis, and hormone balances in breast tissues. On the basis of these notions, we consider how breast cancer is associated to the creation of potentially therapeutic interventions and predictive biomarkers.
引用
收藏
页码:82 / 99
页数:18
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