HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome

被引：21
作者：
Wang, PF
Tan, MH
Zhang, C
Morreau, H
Teh, BT
机构：
[1] Van Andel Res Inst, Canc Genet Lab, Grand Rapids, MI 49503 USA
[2] Alexandra Hosp, Dept Med, Singapore, Singapore
[3] Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands
来源：
HORMONE AND METABOLIC RESEARCH | 2005年 / 37卷 / 06期
关键词：
hyperparathyroidism-jaw tumor syndrome; HRPT2; parafibromin; parathyroid carcinoma;
D O I：
10.1055/s-2005-870150
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.
引用
收藏
页码：380 / 383
页数：4
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