T cell immunity to SARS-CoV-2

被引：65

作者：

Niessl, Julia ^{[1
]}

Sekine, Takuya ^{[1
]}

Buggert, Marcus ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden

来源：

SEMINARS IN IMMUNOLOGY | 2021年 / 55卷

基金：

瑞典研究理事会;

关键词：

SARS-CoV-2; COVID-19; Memory T cells; Vaccine; ANTIVIRAL IMMUNITY; RESPONSES; PROTECTION; DIFFERENTIATION; INDIVIDUALS; INFECTION; SMALLPOX; ANTIBODY;

D O I：

10.1016/j.smim.2021.101505

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exceptional efforts have been undertaken to shed light into the biology of adaptive immune responses to SARS-CoV-2. T cells occupy a central role in adaptive immunity to mediate helper functions to different arms of the immune system and are fundamental to mediate protection, control, and clearance of most viral infections. Even though many questions remain unsolved, there is a growing literature linking specific T cell characteristics to differential COVID-19 severity and vaccine outcome. In this review, we summarize our current understanding of CD4(+) and CD8(+) T cell responses in acute and convalescent COVID-19. Further, we discuss the T cell literature coupled to pre-existing immunity and vaccines and highlight the need to look beyond blood to fully understand how T cells function in the tissue space.

引用

页数：11

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