A role for BDNF in mechanosensation

被引：146

作者：

Carroll, P

Lewin, GR

Koltzenburg, M

Toyka, KV

Thoenen, H

机构：

[1] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany

[2] Max Planck Inst Neurobiol, Dept Neurobiochem, D-82152 Planegg Martinsried, Germany

[3] Max Delbruck Ctr Mol Med, Growth Factor & Regenerat Grp, D-13122 Berlin, Germany

来源：

NATURE NEUROSCIENCE | 1998年 / 1卷 / 01期

关键词：

D O I：

10.1038/242

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a survival factor for certain sensory neurons during development. Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction. Neurons lacking BDNF did not die, but instead showed a profound and specific reduction in their mechanical sensitivity, which was quantitatively the same in BDNF -/- and BDNF +/- animals. Postnatal treatment of BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity deficit. Therefore BDNF is important for regulating SAM mechanosensitivity, independent of any survival-promoting function.

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页码：42 / 46

页数：5

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