Genetic control of cell differentiation in the skeleton

被引：104

作者：

Ducy, P ^{[1
]}

Karsenty, G ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(98)80037-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanisms of cell differentiation in the skeleton are just beginning to be unraveled. In the past year classical gene expression studies, genetic manipulation in mice and human genetic approaches have led to the identification of Osf2/Cbfa1 as a major regulator of osteoblast differentiation. important progress was also made in the understanding of the control of osteoclast differentiation through the identification of osteoprotegerin and its ligand. These studies, as well as others of chondrocyte differentiation, provide a better understanding of skeletogenesis.

引用

页码：614 / 619

页数：6

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