In vitro investigations on CoO doped CaF2-CaO-B2O3-P2O5-MO bioactive glasses by means of spectroscopic studies

In this investigation we have synthesized CaF2-CaO-B2O3-P2O5: CoO glasses mixed with different therapeutically active ions viz., Ba2+, Sr2+, Mg2+ and Zn2+ (that play a vital role in the normal functioning of human body) and performed in vitro bioactivity studies by immersing them in simulated body fluid (SBF) for a period of about a month and the obtained results were analyzed using spectroscopic studies. Due to immersion in SBF solution, a thin layer of hydroxy apatite (HAp) is developed on the surface of the samples. The results of XRD, SEM and also IR spectra have confirmed that the layer deposited on the surface of the samples is crystalline HAp mixed with cobalt ions. The quantitative analysis of the results in vitro bioactive studies with the help of optical absorption and IR spectral studies have indicated that BaO is an efficient modifier in accelerating the HAp growth. The cobalt ions are found to be in tetrahedral positions and participated in the glass network with BO4 and PO4 structural units in larger quantities in Co-zn and Co-mg glasses and such occupancy is found to be the reason for the relatively low bioactive efficiency of these glasses when compared with that of Co-Ba glass. (C) 2017 Elsevier B.V. All rights reserved.