Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study

被引：15

作者：

Cour, Martin ^{[1
,2
]}

Simon, Marie ^{[1
]}

Argaud, Laurent ^{[1
,2
]}

Monneret, Guillaume ^{[2
,3
]}

Venet, Fabienne ^{[2
,3
,4
]}

机构：

[1] Hop Edouard Herriot, Hosp Civils Lyon, Serv Med Intens Reanimat, Intens Care Med, F-69437 Lyon 03, France

[2] Univ Lyon, Fac Med Lyon Est, Univ Claude Bernard Lyon 1, F-69437 Lyon, France

[3] Hop Edouard Herriot, Hosp Civils Lyon, Immunol Lab, F-69437 Lyon, France

[4] Univ Claude, Ecole Normale Super Lyon, Ctr Int Rech Infectiol CIRI, Inserm U1111,CNRS,UMR5308, Bernard Lyon 1, Lyon, France

来源：

JOURNAL OF INTENSIVE CARE | 2021年 / 9卷 / 01期

关键词：

SARS-CoV-2; Monocyte HLA-DR; CD4+lymphocyte; Nosocomial infection; Intensive care unit;

D O I：

10.1186/s40560-021-00580-6

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Dexamethasone improves survival of patients with COVID-19 acute respiratory distress syndrome, but might shorten the delay between the start of invasive mechanical ventilation and the occurrence of ventilator-associated pneumonia, suggesting possible worsening of COVID-19-induced immune dysfunction with this treatment. In a prospective observational study, we found that mechanically ventilated patients with COVID-19 treated with dexamethasone presented earlier ventilator-associated pneumonia, had significantly lower monocyte Human Leukocyte Antigen-DR expression and number of circulating CD4 + cells after ICU admission, than those not treated with corticoids.

引用

页数：4

共 7 条

[1] Impact of dexamethasone on the incidence of ventilator-associated pneumonia and blood stream infections in COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective study [J].