Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam

被引：4

作者：

Sawagashira, Ryo ^{[1
]}

Narita, Hisashi ^{[2
]}

Hashimoto, Naoki ^{[2
]}

Kurita, Tsugiko ^{[2
]}

Nakagawa, Shin ^{[2
]}

Saitoh, Takuya ^{[3
]}

Kusumi, Ichiro ^{[2
]}

机构：

[1] Otaru Gen Hosp, Dept Psychiat, Otaru, Hokkaido, Japan

[2] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Sapporo, Hokkaido, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Child & Adolescent Psychiat, Sapporo, Hokkaido, Japan

来源：

EPILEPTIC DISORDERS | 2017年 / 19卷 / 03期

关键词：

Transient lesion; splenium of the corpus callosum; MRI; levetiracetam; drug side-effect; anticonvulsant; HYPONATREMIA;

D O I：

10.1684/epd.2017.0923

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transient lesions of the splenium of the corpus callosum are characterized by MRI findings. The lesions are very rare, but significant from a clinical standpoint as differential diagnoses include serious conditions such as encephalitis, meningitis, and neuroleptic malignant syndrome. In addition, it is reported that some are attributed to the withdrawal of antiepileptic drugs. Here, we present a case of transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam alone. To the best of our knowledge, this is the first report of such a case. Moreover, it is reported that cases of incidental transient lesions of the splenium of the corpus callosum are detected in Japan more often than in other countries, and as a result are prone to over-triage. Taking this into consideration, in the event of transient lesions of the splenium of the corpus callosum, the utmost attention must be paid to clinical symptoms and history relating to any of the aforementioned serious conditions.

引用

页码：379 / 382

页数：4

共 43 条

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