Localization and modulation of ErbB receptor tyrosine kinases

被引：48

作者：

Carraway, KL ^{[1
]}

Sweeney, C

机构：

[1] Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02215 USA

[2] Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(00)00188-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling. The past year has witnessed significant advances in our understanding of the molecular mechanisms of ErbB localization and the role of PDZ-domain-containing proteins and cell-surface glycoproteins in directly modulating signaling through ErbBs.

引用

页码：125 / 130

页数：6

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