Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics

被引：39
作者：
Akhtar, Saghir [1 ]
机构：
[1] Kuwait Univ, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Fac Med, Safat 13110, Kuwait
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2010年 / 6卷 / 11期
关键词：
GENE-EXPRESSION CHANGES; IN-VIVO; ANTISENSE OLIGONUCLEOTIDES; DRUG-DELIVERY; RNA INTERFERENCE; SIRNA DELIVERY; POLYPROPYLENIMINE DENDRIMERS; MODIFIED POLYETHYLENIMINES; TARGETED NANOPARTICLES; PAMAM DENDRIMERS;
D O I：
10.1517/17425255.2010.518611
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Areas covered in this review: A combination of highly focused and comprehensive literature searches to identify any relevant reports using Medline (from 1950 to 7 April 2010) through the OVID system. What the reader will gain: Using cationic delivery nanosystems as examples, this review article highlights the importance of undertaking toxicogenomics studies - the application of transcription profiling to toxicology - to acquire gene expression signatures of siRNA delivery systems so as to determine and/or predict their impact on gene silencing activity and specificity. Such nanotoxicological information will be important for the optimal selection of siRNA-delivery system combinations in the many proposed clinical applications of RNA interference. Take home message: Cationic delivery nanosystems can elicit multiple gene expression changes in cells that may contribute to the 'off-target' effects of siRNAs and/or modulate their pharmacological activity. Thus, selection of delivery systems for siRNA applications should be based on both their delivery enhancing capability and toxicogenomics.
引用
收藏
页码：1347 / 1362
页数：16
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